Syllabic discrimination in premature human infants prior to complete formation of cortical layers
Identifieur interne : 000015 ( France/Analysis ); précédent : 000014; suivant : 000016Syllabic discrimination in premature human infants prior to complete formation of cortical layers
Auteurs : Mahdi Mahmoudzadeh [France] ; Ghislaine Dehaene-Lambertz [France] ; Marc Fournier [France] ; Guy Kongolo [France] ; Sabrina Goudjil [France] ; Jessica Dubois [France] ; Reinhard Grebe [France] ; Fabrice Wallois [France]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2013.
Abstract
The ontogeny of linguistic functions in the human brain remains elusive. Although some auditory capacities are described before term, whether and how such immature cortical circuits might process speech are unknown. Here we used functional optical imaging to evaluate the cerebral responses to syllables at the earliest age at which cortical responses to external stimuli can be recorded in humans (28- to 32-wk gestational age). At this age, the cortical organization in layers is not completed. Many neurons are still located in the subplate and in the process of migrating to their final location. Nevertheless, we observed several points of similarity with the adult linguistic network. First, whereas syllables elicited larger right than left responses, the posterior temporal region escaped this general pattern, showing faster and more sustained responses over the left than over the right hemisphere. Second, discrimination responses to a change of phoneme (ba vs. ga) and a change of human voice (male vs. female) were already present and involved inferior frontal areas, even in the youngest infants (29-wk gestational age). Third, whereas both types of changes elicited responses in the right frontal region, the left frontal region only reacted to a change of phoneme. These results demonstrate a sophisticated organization of perisylvian areas at the very onset of cortical circuitry, 3 mo before term. They emphasize the influence of innate factors on regions involved in linguistic processing and social communication in humans.
Url:
DOI: 10.1073/pnas.1212220110
PubMed: 23440196
PubMed Central: 3607062
Affiliations:
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and" id="aff3">Commissariat à l’Energie Atomique,<institution>NeuroSpin</institution>, F91191 Gif-sur-Yvette,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Université Paris XI</institution>, F91405 Orsay,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fournier, Marc" sort="Fournier, Marc" uniqKey="Fournier M" first="Marc" last="Fournier">Marc Fournier</name><affiliation wicri:level="1"><nlm:aff id="aff1">Institut National de la Santé et de la Recherche Médicale (INSERM) U1105, GRAMFC,<institution>Université de Picardie Jules Verne, CHU Amiens</institution>, F80000 Amiens,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kongolo, Guy" sort="Kongolo, Guy" uniqKey="Kongolo G" first="Guy" last="Kongolo">Guy Kongolo</name><affiliation wicri:level="1"><nlm:aff id="aff1">Institut National de la Santé et de la Recherche Médicale (INSERM) U1105, GRAMFC,<institution>Université de Picardie Jules Verne, CHU Amiens</institution>, F80000 Amiens,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Goudjil, Sabrina" sort="Goudjil, Sabrina" uniqKey="Goudjil S" first="Sabrina" last="Goudjil">Sabrina Goudjil</name><affiliation wicri:level="1"><nlm:aff id="aff1">Institut National de la Santé et de la Recherche Médicale (INSERM) U1105, GRAMFC,<institution>Université de Picardie Jules Verne, CHU Amiens</institution>, F80000 Amiens,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dubois, Jessica" sort="Dubois, Jessica" uniqKey="Dubois J" first="Jessica" last="Dubois">Jessica Dubois</name><affiliation wicri:level="1"><nlm:aff id="aff2">INSERM U992,<institution>Cognitive Neuroimaging Unit</institution>, F91191 Gif-sur-Yvette,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff3">Commissariat à l’Energie Atomique,<institution>NeuroSpin</institution>, F91191 Gif-sur-Yvette,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Université Paris XI</institution>, F91405 Orsay,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Grebe, Reinhard" sort="Grebe, Reinhard" uniqKey="Grebe R" first="Reinhard" last="Grebe">Reinhard Grebe</name><affiliation wicri:level="1"><nlm:aff id="aff1">Institut National de la Santé et de la Recherche Médicale (INSERM) U1105, GRAMFC,<institution>Université de Picardie Jules Verne, CHU Amiens</institution>, F80000 Amiens,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wallois, Fabrice" sort="Wallois, Fabrice" uniqKey="Wallois F" first="Fabrice" last="Wallois">Fabrice Wallois</name><affiliation wicri:level="1"><nlm:aff id="aff1">Institut National de la Santé et de la Recherche Médicale (INSERM) U1105, GRAMFC,<institution>Université de Picardie Jules Verne, CHU Amiens</institution>, F80000 Amiens,<country>France</country>;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="e-ISSN">1091-6490</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The ontogeny of linguistic functions in the human brain remains elusive. Although some auditory capacities are described before term, whether and how such immature cortical circuits might process speech are unknown. Here we used functional optical imaging to evaluate the cerebral responses to syllables at the earliest age at which cortical responses to external stimuli can be recorded in humans (28- to 32-wk gestational age). At this age, the cortical organization in layers is not completed. Many neurons are still located in the subplate and in the process of migrating to their final location. Nevertheless, we observed several points of similarity with the adult linguistic network. First, whereas syllables elicited larger right than left responses, the posterior temporal region escaped this general pattern, showing faster and more sustained responses over the left than over the right hemisphere. Second, discrimination responses to a change of phoneme (ba vs. ga) and a change of human voice (male vs. female) were already present and involved inferior frontal areas, even in the youngest infants (29-wk gestational age). Third, whereas both types of changes elicited responses in the right frontal region, the left frontal region only reacted to a change of phoneme. These results demonstrate a sophisticated organization of perisylvian areas at the very onset of cortical circuitry, 3 mo before term. They emphasize the influence of innate factors on regions involved in linguistic processing and social communication in humans.</p></div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><country name="France"><noRegion><name sortKey="Mahmoudzadeh, Mahdi" sort="Mahmoudzadeh, Mahdi" uniqKey="Mahmoudzadeh M" first="Mahdi" last="Mahmoudzadeh">Mahdi Mahmoudzadeh</name></noRegion><name sortKey="Dehaene Lambertz, Ghislaine" sort="Dehaene Lambertz, Ghislaine" uniqKey="Dehaene Lambertz G" first="Ghislaine" last="Dehaene-Lambertz">Ghislaine Dehaene-Lambertz</name><name sortKey="Dehaene Lambertz, Ghislaine" sort="Dehaene Lambertz, Ghislaine" uniqKey="Dehaene Lambertz G" first="Ghislaine" last="Dehaene-Lambertz">Ghislaine Dehaene-Lambertz</name><name sortKey="Dehaene Lambertz, Ghislaine" sort="Dehaene Lambertz, Ghislaine" uniqKey="Dehaene Lambertz G" first="Ghislaine" last="Dehaene-Lambertz">Ghislaine Dehaene-Lambertz</name><name sortKey="Dubois, Jessica" sort="Dubois, Jessica" uniqKey="Dubois J" first="Jessica" last="Dubois">Jessica Dubois</name><name sortKey="Dubois, Jessica" sort="Dubois, Jessica" uniqKey="Dubois J" first="Jessica" last="Dubois">Jessica Dubois</name><name sortKey="Dubois, Jessica" sort="Dubois, Jessica" uniqKey="Dubois J" first="Jessica" last="Dubois">Jessica Dubois</name><name sortKey="Fournier, Marc" sort="Fournier, Marc" uniqKey="Fournier M" first="Marc" last="Fournier">Marc Fournier</name><name sortKey="Goudjil, Sabrina" sort="Goudjil, Sabrina" uniqKey="Goudjil S" first="Sabrina" last="Goudjil">Sabrina Goudjil</name><name sortKey="Grebe, Reinhard" sort="Grebe, Reinhard" uniqKey="Grebe R" first="Reinhard" last="Grebe">Reinhard Grebe</name><name sortKey="Kongolo, Guy" sort="Kongolo, Guy" uniqKey="Kongolo G" first="Guy" last="Kongolo">Guy Kongolo</name><name sortKey="Wallois, Fabrice" sort="Wallois, Fabrice" uniqKey="Wallois F" first="Fabrice" last="Wallois">Fabrice Wallois</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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